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The antibody against GALNT12 was raised in rabbit using the Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against GALNT12 was raised in rabbit using the Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human gastric cancer using GALNT12 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using GALNT12 Antibody at dilution of 1:1002
| Cat.No | ADC-24841A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GALNT12 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 12 protein (1-272AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IXK2 |
Uniprot Id
Q8IXK2
Target Species
Human
Target Name
GALNT12
Target Full Name
Polypeptide N-acetylgalactosaminyltransferase 12
Target Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Target Involvement
Colorectal cancer 1 (CRCS1)
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 2 family, GalNAc-T subfamily
Target Tissue Specificity
Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral c
Target Synonyms
Colorectal cancer susceptibility to 1; CRCS1; FLJ21212; GalNAc T12; GalNAc-T12; GalNAcT12; GALNT 12; Galnt12; GLT12_HUMAN; Polypeptide GalNAc transferase 12; Polypeptide N acetylgalactosaminyltransferase 12; Polypeptide N-acetylgalactosaminyltransferase 12; pp GaNTase 12; pp-GaNTase 12; Protein UDP acetylgalactosaminyltransferase 12; Protein-UDP acetylgalactosaminyltransferase 12; UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12 ; UDP GalNAc polypeptide N acetylgalactosaminyltransferase; UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12
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