Rabbit anti-Human COX6B2 Polyclonal Antibody

Uniprot Id

Q6YFQ2

Target Species

Human

Target Name

COX6B2

Target Full Name

Cytochrome c oxidase subunit 6B2

Target Function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Target Protein Families

Cytochrome c oxidase subunit 6B family

Target Tissue Specificity

Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.

Target Synonyms

COX6B2Cytochrome c oxidase subunit 6B2; Cancer/testis antigen 59; CT59; Cytochrome c oxidase subunit VIb isoform 2; COX VIb-2; Cytochrome c oxidase subunit VIb; testis-specific isoform