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The antibody against TRIM72 was raised in rabbit using the Recombinant Protein as the immunogen. This antibody exists as a non-conjugated isotype IgG. This antibody has been validated on WB, IHC.
The antibody against TRIM72 was raised in rabbit using the Recombinant Protein as the immunogen. This antibody exists as a non-conjugated isotype IgG. This antibody has been validated on WB, IHC.
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Immunohistochemical analysis of paraffin-embedded Mouse PancreasTissue using TRIM72 Polyclonal Antibody.
Western blot analysis of Mouse skeletal muscle using TRIM72 Polyclonal Antibody.2
| Cat.No | ADC-33157A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIM72 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | PH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol., PBS |
| Conjugate | Non-conjugated | Application | IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Protein | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6ZMU5 |
Uniprot Id
Q6ZMU5
Target Species
Human
Target Name
TRIM72
Target Full Name
Tripartite motif-containing protein 72
Target Function
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
Target Subcellular Location
Cell membrane, sarcolemma. Cytoplasmic vesicle membrane.
Target Protein Families
TRIM/RBCC family
Target Research Area
Transport, Cell Biology
Target Synonyms
LOC493829; Mg53; Mitsugumin-53; TRI72_HUMAN; trim72; Tripartite motif containing 72; Tripartite motif containing protein 72 ; Tripartite motif-containing protein 72
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