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The antibody against EDN1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human ET-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against EDN1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human ET-1. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of mouse lung cells using ET-1 Polyclonal Antibody
| Cat.No | ADC-37202A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EDN1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human ET-1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P05305 |
Uniprot Id
P05305
Target Species
Human
Target Name
EDN1
Target Full Name
Endothelin-1
Target Function
Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells.
Target Involvement
Question mark ears, isolated (QME); Auriculocondylar syndrome 3 (ARCND3)
Target Subcellular Location
Secreted.
Target Protein Families
Endothelin/sarafotoxin family
Target Tissue Specificity
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.
Target Research Area
Signal Transduction
Target Synonyms
ARCND3; Big endothelin-1; EDN1; EDN1_HUMAN; ET-1; ET1; HDLCQ7; PPET1; Preproendothelin 1; Preproendothelin-1; QME
Target Background
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.
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