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The antibody against MUTYH was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MYH. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
The antibody against MUTYH was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MYH. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, IF, ELISA.
$167.00
Western Blot analysis of HepG2 cells using MYH Polyclonal Antibody
| Cat.No | ADC-38161A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MUTYH |
| Target Synonyms | E. coli, homolog of antibody; Mutyh antibody; MUTYH_HUMAN antibody; MYH antibody; rMYH antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human MYH. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UIF7 |
Uniprot Id
Q9UIF7
Target Species
Human
Target Name
MUTYH
Target Full Name
Adenine DNA glycosylase
Target Function
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Target Involvement
Familial adenomatous polyposis 2 (FAP2); Gastric cancer (GASC)
Target Subcellular Location
Nucleus. Mitochondrion.
Target Protein Families
Nth/MutY family
Target Synonyms
A/G specific adenine DNA glycosylase; A/G-specific adenine DNA glycosylase; Adenine DNA glycosylase ; CYP2C; hMYH; MGC4416; MutY (E. coli) homolog ; MutY homolog (E. coli); MutY homolog; MutY, E. coli, homolog of; Mutyh; MUTYH_HUMAN; MYH; rMYH
Target Background
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7, 8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.
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