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The antibody against EIF4EBP3 was raised in rabbit using the Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against EIF4EBP3 was raised in rabbit using the Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human pancreatic tissue using EIF4EBP3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using EIF4EBP3 Antibody at dilution of 1:1002
| Cat.No | ADC-43920A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EIF4EBP3 |
| Target Synonyms | EIF4EBP3Eukaryotic translation initiation factor 4E-binding protein 3 antibody; 4E-BP3 antibody; eIF4E-binding protein 3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 3 protein (1-100AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O60516 |
Uniprot Id
O60516
Target Species
Human
Target Name
EIF4EBP3
Target Full Name
Eukaryotic translation initiation factor 4E-binding protein 3
Target Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
Target Protein Families
EIF4E-binding protein family
Target Tissue Specificity
Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
EIF4EBP3Eukaryotic translation initiation factor 4E-binding protein 3; 4E-BP3; eIF4E-binding protein 3
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