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The antibody against N was raised in rabbit using the Recombinant Rabies virus Nucleoprotein protein (1-450AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against N was raised in rabbit using the Recombinant Rabies virus Nucleoprotein protein (1-450AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49863A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | N |
| Target Synonyms | N antibody; Nucleoprotein antibody; NP antibody; Nucleocapsid protein antibody; Protein N antibody | Form | Liquid |
| Species Reactivity | Rabies virus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Rabies virus Nucleoprotein protein (1-450AA) | Target Species | Rabies virus |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P15197 |
Uniprot Id
P15197
Target Species
Rabies virus
Target Name
N
Target Function
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.
Target Subcellular Location
Virion. Host cytoplasm.
Target Protein Families
Lyssavirus nucleocapsid protein family
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