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The antibody against HEPACAM was raised in rabbit using the Recombinant Human Hepatocyte cell adhesion molecule protein (265-415AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against HEPACAM was raised in rabbit using the Recombinant Human Hepatocyte cell adhesion molecule protein (265-415AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-06906A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HEPACAM |
| Target Synonyms | FLJ25530 antibody; GlialCAM antibody; HECAM_HUMAN antibody; HEPACAM antibody; Hepatocyte cell adhesion molecule antibody; Protein hepaCAM antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Hepatocyte cell adhesion molecule protein (265-415AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14CZ8 |
Uniprot Id
Q14CZ8
Target Species
Human
Target Name
HEPACAM
Target Full Name
Hepatic and glial cell adhesion molecule
Target Function
Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.
Target Involvement
Leukoencephalopathy, megalencephalic, with subcortical cysts, 2A (MLC2A); Leukoencephalopathy, megalencephalic, with subcortical cysts, 2B (MLC2B)
Target Subcellular Location
Cytoplasm. Membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.
Target Synonyms
FLJ25530; GlialCAM; HECAM_HUMAN; HEPACAM; Hepatocyte cell adhesion molecule; Protein hepaCAM
Target Background
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.
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