Rabbit anti-Human PSCA Polyclonal Antibody

The antibody against PSCA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 12-114 of human PSCA (NP_005663.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-03740A

Number

Cat.No	ADA-03740A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PSCA
Target Synonyms	PRO232; lncPSCA; PSCA	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, PC-3	Application	ELISA, WB

Cat.No

ADA-03740A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PSCA

Target Synonyms

PRO232; lncPSCA; PSCA

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, PC-3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 12-114 of human PSCA (NP_005663.2).	Target Species	Human
Immunogen Sequence	LLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL	Uniprot ID	O43653

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 12-114 of human PSCA (NP_005663.2).

Target Species

Human

Immunogen Sequence

LLCYSCKAQVSNEDCLQVENCTQLGEQCWTARIRAVGLLTVISKGCSLNCVDDSQDYYVGKKNITCCDTDLCNASGAHALQPAAAILALLPALGLLLWGPGQL

Uniprot ID

O43653

Background Information

Uniprot Id

O43653
Target Species

Human
Target Name

PSCA
Target Full Name

Prostate stem cell antigen
Target Function

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.; May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.
Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.
Target Tissue Specificity

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Over
Target Research Area

Cancer, Tags & Cell Markers
Target Synonyms

PSCA; UNQ206/PRO232; Prostate stem cell antigen
Target Background

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human PSCA Polyclonal Antibody

Specifications

Immunogen Information

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