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The antibody against HDAC10 was raised in Rabbit using a synthesized peptide derived from human HDAC10 as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HDAC10 was raised in Rabbit using a synthesized peptide derived from human HDAC10 as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of MCF7, using HDAC10 Rabbit pAb at 1:600 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
| Cat.No | ADA-10663A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HDAC10 |
| Target Synonyms | HD10; [KD Validated] HDAC10 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T(KD), MCF7 | Application | ELISA, WB |
| Immunogen Description | A synthesized peptide derived from human HDAC10. | Uniprot ID | Q969S8 |
|---|---|---|---|
| Immunogen Sequence |
Uniprot Id
Q969S8
Target Species
Human
Target Name
HDAC10
Target Full Name
Polyamine deacetylase HDAC10
Target Function
Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Histone deacetylase family, HD type 2 subfamily
Target Tissue Specificity
Widely expressed with high levels in liver and kidney.
Target Synonyms
DKFZP761B039; HD 10; HD10; HDA10_HUMAN; HDAC 10; Hdac10; Histone deacetylase 10; MGC149722; OTTHUMP00000028555
Target Background
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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