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The antibody against ADPRHL2 was raised in rabbit using the Synthetic peptide of Human ADPRHL2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against ADPRHL2 was raised in rabbit using the Synthetic peptide of Human ADPRHL2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-27230A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ADPRHL2 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human ADPRHL2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NX46 |
Uniprot Id
Q9NX46
Target Species
Human
Target Name
ADPRS
Target Full Name
ADP-ribosylhydrolase ARH3
Target Function
ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers.
Target Subcellular Location
Nucleus. Cytoplasm. Chromosome. Mitochondrion matrix.
Target Protein Families
ADP-ribosylglycohydrolase family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
[Protein ADP ribosylarginine] hydrolase like protein 2; [Protein ADP-ribosylarginine] hydrolase-like protein 2; ADP ribosylhydrolase 3; ADP ribosylhydrolase like 2; ADP-ribosylhydrolase 3; Adprhl2; AI836109; ARH3; ARHL2_HUMAN; ecto ADP ribosylhydrolase; FLJ20446; OTTMUSP00000009757; Poly(ADP ribose) glycohydrolase ARH3; Poly(ADP-ribose) glycohydrolase ARH3; Protein ADP ribosylarginine hydrolase like protein 2; RP23-113P22.3
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