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The antibody against AFAP1 was raised in rabbit using the Fusion protein of Human AFAP1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against AFAP1 was raised in rabbit using the Fusion protein of Human AFAP1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using AFAP1 Antibody(AFAP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: X200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using AFAP1 Antibody(AFAP1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: X200)2
| Cat.No | ADC-31037A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AFAP1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Fusion protein of Human AFAP1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N556 |
Uniprot Id
Q8N556
Target Species
Human
Target Name
AFAP1
Target Full Name
Actin filament-associated protein 1
Target Function
Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
Target Subcellular Location
Cytoplasm, cytoskeleton, stress fiber.
Target Tissue Specificity
Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.
Target Synonyms
110 kDa actin filament associated protein; 110 kDa actin filament-associated protein; Actin filament associated protein 1; Actin filament associated protein 110 kDa; Actin filament-associated protein 1; AFAP 1; AFAP 110; AFAP; AFAP-110; Afap1; AFAP1_HUMAN; AFAP110; FLJ56849
Target Background
The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene.
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