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The antibody against AHCY was raised in rabbit using the Recombinant Human Adenosylhomocysteinase protein (2-432AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against AHCY was raised in rabbit using the Recombinant Human Adenosylhomocysteinase protein (2-432AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-50208A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AHCY |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Adenosylhomocysteinase protein (2-432AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P23526 |
Uniprot Id
P23526
Target Species
Human
Target Name
AHCY
Target Full Name
Adenosylhomocysteinase
Target Function
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Target Involvement
Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Target Subcellular Location
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Target Protein Families
Adenosylhomocysteinase family
Target Research Area
Metabolism
Target Synonyms
Adenosylhomocysteinase; AdoHcyase; ahcY; S adenosyl L homocysteine hydrolase; S adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase; SAHH; SAHH_HUMAN
Target Background
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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