Rabbit anti-Human ALKBH5 Polyclonal Antibody

The antibody against ALKBH5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 245-394 of human ALKBH5 (NP_060228.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-12633A

Number

Cat.No	ADA-12633A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ALKBH5
Target Synonyms	ABH5; OFOXD; OFOXD1; ALKBH5	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, Mouse testis, Rat skeletal muscle	Application	ELISA, WB, IHC-P

Cat.No

ADA-12633A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ALKBH5

Target Synonyms

ABH5; OFOXD; OFOXD1; ALKBH5

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, Mouse testis, Rat skeletal muscle

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 245-394 of human ALKBH5 (NP_060228.3).	Target Species	Human
Immunogen Sequence	SLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSSVLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH	Uniprot ID	Q6P6C2

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 245-394 of human ALKBH5 (NP_060228.3).

Target Species

Human

Immunogen Sequence

SLPVRRGSVTVLSGYAADEITHCIRPQDIKERRAVIILRKTRLDAPRLETKSLSSSVLPPSYASDRLSGNNRDPALKPKRSHRKADPDAAHRPRILEMDKEENRRSVLLPTHRRRGSFSSENYWRKSYESSEDCSEAAGSPARKVKMRRH

Uniprot ID

Q6P6C2

Background Information

Uniprot Id

Q6P6C2
Target Species

Human
Target Name

ALKBH5
Target Full Name

RNA demethylase ALKBH5
Target Function

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells.
Target Subcellular Location

Nucleus speckle.
Target Protein Families

AlkB family
Target Tissue Specificity

Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.
Target Synonyms

ALKBH5; ABH5; OFOXD1RNA demethylase ALKBH5; EC 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
Target Background

Enables mRNA N6-methyladenosine dioxygenase activity. Involved in RNA metabolic process; mRNA export from nucleus; and response to hypoxia. Located in Golgi apparatus; cytosol; and nuclear speck.

Rabbit anti-Human ALKBH5 Polyclonal Antibody

Specifications

Immunogen Information

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