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The antibody against AOC3 was raised in rabbit using the Recombinant Human Membrane primary amine oxidase protein (27-259AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against AOC3 was raised in rabbit using the Recombinant Human Membrane primary amine oxidase protein (27-259AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human endometrial cancer using AOC3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using AOC3 Antibody at dilution of 1:1002
Immunofluorescent analysis of A549 cells using AOC3 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-08766A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AOC3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Membrane primary amine oxidase protein (27-259AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q16853 |
Uniprot Id
Q16853
Target Species
Human
Target Name
AOC3
Target Full Name
Amine oxidase [copper-containing] 3
Target Function
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Target Protein Families
Copper/topaquinone oxidase family
Target Tissue Specificity
Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, p
Target Synonyms
Amine oxidase; copper containing 3 (vascular adhesion protein 1); AOC3; AOC3_HUMAN; Copper amine oxidase; HPAO; Membrane copper amine oxidase; Membrane primary amine oxidase; Semicarbazide sensitive amine oxidase; Semicarbazide-sensitive amine oxidase; SSAO; VAP-1; Vascular adhesion protein 1; VP97
Target Background
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
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