Rabbit anti-Human APOBEC3D/APOBEC3F Polyclonal Antibody

Uniprot Id

Q96AK3

Target Species

Human

Target Name

APOBEC3D

Target Full Name

DNA dC->dU-editing enzyme APOBEC-3D

Target Function

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

Target Subcellular Location

Cytoplasm. Cytoplasm, P-body.

Target Protein Families

Cytidine and deoxycytidylate deaminase family

Target Tissue Specificity

Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung.

Target Synonyms

A3D; ABC3D_HUMAN; APOBEC3D; APOBEC3DE; APOBEC3E; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3D; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3E pseudogene; ARP6; bK150C2.9; BK150C2.9 protein; DNA dC >dU editing enzyme APOBEC 3D; DNA dC->dU-editing enzyme APOBEC-3D; hCG_41704; HCG41704; isoform CRA_b; Probable DNA dC->dU-editing enzyme APOBEC-3D

Target Background

This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.