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The antibody against ARHGEF12 was raised in rabbit using the Recombinant Human Rho guanine nucleotide exchange factor 12 protein (1302-1501AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against ARHGEF12 was raised in rabbit using the Recombinant Human Rho guanine nucleotide exchange factor 12 protein (1302-1501AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using ARHGEF12 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using ARHGEF12 Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using ARHGEF12 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-08147A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ARHGEF12 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Rho guanine nucleotide exchange factor 12 protein (1302-1501AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NZN5 |
Uniprot Id
Q9NZN5
Target Species
Human
Target Name
ARHGEF12
Target Full Name
Rho guanine nucleotide exchange factor 12
Target Function
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Target Involvement
A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1.
Target Subcellular Location
Cytoplasm. Membrane.
Target Tissue Specificity
Ubiquitously expressed. Isoform 2 is found in jejunum and testis.
Target Research Area
Signal Transduction
Target Synonyms
ARHGC_HUMAN; ARHGEF12; KIAA0382; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine exchange factor (GEF) 12; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12; Similar to Mouse Lsc oncogene
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