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The antibody against ATAD1 was raised in rabbit using the Recombinant Human ATPase family AAA domain-containing protein 1 protein (289-350AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against ATAD1 was raised in rabbit using the Recombinant Human ATPase family AAA domain-containing protein 1 protein (289-350AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-10178A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATAD1 |
| Target Synonyms | AAA domain containing 1 antibody; ATPase Thorase antibody; AW107648 antibody; FLJ14600 antibody; FNP001 antibody; Thorase antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human ATPase family AAA domain-containing protein 1 protein (289-350AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8NBU5 |
Uniprot Id
Q8NBU5
Target Species
Human
Target Name
ATAD1
Target Full Name
Outer mitochondrial transmembrane helix translocase
Target Function
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane. Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent.
Target Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Single-pass membrane protein.
Target Protein Families
AAA ATPase family
Target Synonyms
4921525H23Rik; AAA+ ATPase Thorase; Ab2-088; AFDC1; Atad1; ATAD1_HUMAN; ATPase family AAA domain containing protein 1; ATPase family AAA domain-containing protein 1; ATPase family, AAA domain containing 1; ATPase Thorase; AW107648; FLJ14600; FNP001; Thorase
Target Background
Predicted to enable ATP binding activity and transmembrane protein dislocase activity. Involved in extraction of mislocalized protein from mitochondrial outer membrane. Located in mitochondrial outer membrane and peroxisomal membrane. Implicated in hyperekplexia 4.
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