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The antibody against B3GNT5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 36-378 of human B3GNT5 (NP_114436.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against B3GNT5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 36-378 of human B3GNT5 (NP_114436.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00651A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | B3GNT5 |
| Target Synonyms | B3GN-T5; beta3Gn-T5; B3GNT5 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, HT-29 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 36-378 of human B3GNT5 (NP_114436.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BYG0 | Immunogen Sequence |
Uniprot Id
Q9BYG0
Target Species
Human
Target Name
B3GNT5
Target Full Name
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Target Function
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 31 family
Target Tissue Specificity
Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus.
Target Research Area
Tags & Cell Markers
Target Synonyms
B3GNT5Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; EC 2.4.1.206; Lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; BGnT-5; Beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5
Target Background
This gene encodes a member of the beta-1, 3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids.
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