Rabbit anti-Human BACE2 Polyclonal Antibody

Uniprot Id

Q9Y5Z0

Target Species

Human

Target Name

BACE2

Target Full Name

Beta-secretase 2

Target Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome.

Target Protein Families

Peptidase A1 family

Target Tissue Specificity

Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed

Target Synonyms

ALP 56; ALP56; Asp 1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase

Target Background

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.