Rabbit anti-Human CACNA1A Polyclonal Antibody

Uniprot Id

O00555

Target Species

Human

Target Name

CACNA1A

Target Full Name

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Target Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282). They are however insensitive to dihydropyridines (DHP).

Target Involvement

Spinocerebellar ataxia 6 (SCA6); Migraine, familial hemiplegic, 1 (FHM1); Episodic ataxia 2 (EA2); Epileptic encephalopathy, early infantile, 42 (EIEE42)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1A subfamily

Target Tissue Specificity

Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-ty

Target Synonyms

CACNA1A; CACH4; CACN3; CACNL1A4; Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Brain calcium channel I; BI; Calcium channel; L type; alpha-1 polypeptide isoform 4; Voltage-gated calcium channel subunit alpha Cav2.1