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The antibody against CACNA2D4 was raised in rabbit using the Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-4 protein (934-1115AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against CACNA2D4 was raised in rabbit using the Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-4 protein (934-1115AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CACNA2D4 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human heart tissue using CACNA2D4 Antibody at dilution of 1:1002
| Cat.No | ADC-19360A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACNA2D4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Voltage-dependent calcium channel subunit alpha-2/delta-4 protein (934-1115AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z3S7 |
Uniprot Id
Q7Z3S7
Target Species
Human
Target Name
CACNA2D4
Target Full Name
Voltage-dependent calcium channel subunit alpha-2/delta-4
Target Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.
Target Involvement
Retinal cone dystrophy 4 (RCD4)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Calcium channel subunit alpha-2/delta family
Target Tissue Specificity
Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pi
Target Synonyms
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4; Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4]
Target Background
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
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