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The antibody against CARS was raised in rabbit using the Recombinant Human Cysteine--tRNA ligase, cytoplasmic protein (201-500AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against CARS was raised in rabbit using the Recombinant Human Cysteine–tRNA ligase, cytoplasmic protein (201-500AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-22193A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CARS |
| Target Synonyms | Cysteine tRNA ligase antibody; Cars antibody; CysRS antibody; Cysteine--tRNA ligase antibody; Cysteinyl tRNA synthetase, cytoplasmic antibody; Cysteinyl-tRNA synthetase antibody; cytoplasmic antibody; MGC:11246 antibody; SYCC_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cysteine--tRNA ligase, cytoplasmic protein (201-500AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49589 |
Uniprot Id
P49589
Target Species
Human
Target Name
CARS1
Target Full Name
Cysteine--tRNA ligase, cytoplasmic
Target Function
Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
Target Involvement
A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Class-I aminoacyl-tRNA synthetase family
Target Synonyms
Cysteine tRNA ligase; Cars; CysRS; Cysteine--tRNA ligase; Cysteinyl tRNA synthetase, cytoplasmic; Cysteinyl-tRNA synthetase; cytoplasmic; MGC:11246; SYCC_HUMAN
Target Background
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.
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