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The antibody against CASP12 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Caspase12. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against CASP12 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Caspase12. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western Blot analysis of HuvEc cells using Caspase12 Polyclonal Antibody
| Cat.No | ADC-39142A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CASP12 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Caspase12. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6UXS9 |
Uniprot Id
Q6UXS9
Target Species
Human
Target Name
CASP12
Target Full Name
Inactive caspase-12
Target Function
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Target Protein Families
Peptidase C14A family
Target Tissue Specificity
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
Target Synonyms
CASP 12; CASP-12; Casp12; CASP12P1; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; CASPC_HUMAN; Inactive caspase-12; OTTHUMP00000207032
Target Background
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
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