Rabbit anti-Human CAST Polyclonal Antibody

The antibody against CAST was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 510-610 of human CAST (NP_001177371.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-16726A

Number

Cat.No	ADA-16726A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CAST
Target Synonyms	BS-17; PLACK; ST	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-549, HepG2, MCF-7, Mouse lung, Rat liver, SW480	Application	ELISA, WB

Cat.No

ADA-16726A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CAST

Target Synonyms

BS-17; PLACK; ST

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-549, HepG2, MCF-7, Mouse lung, Rat liver, SW480

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 510-610 of human CAST (NP_001177371.1).	Target Species	Human
Immunogen Sequence	QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD	Uniprot ID	P20810

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 510-610 of human CAST (NP_001177371.1).

Target Species

Human

Immunogen Sequence

QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD

Uniprot ID

P20810

Background Information

Uniprot Id

P20810
Target Species

Human
Target Name

CAST
Target Full Name

Calpastatin
Target Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.
Target Involvement

Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK)
Target Protein Families

Protease inhibitor I27 (calpastatin) family
Target Research Area

Neuroscience
Target Synonyms

BS 17; Calpain inhibitor; Calpastatin; Cast; Heart type calpastatin ; ICAL_HUMAN; MGC9402; Sperm BS 17 component ; Sperm BS-17 component
Target Background

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

Rabbit anti-Human CAST Polyclonal Antibody

Specifications

Immunogen Information

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