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The antibody against CASTOR2 was raised in rabbit using the Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against CASTOR2 was raised in rabbit using the Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
Western Blot | Positive WB detected in: HL60 whole cell lysate, SH-SY5Y whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate | All lanes: CASTOR2 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 37 kDa | Observed band size: 37 kDa
| Cat.No | ADC-01224A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CASTOR2 |
| Target Synonyms | CASTOR2 antibody; Cellular arginine sensor for mTORC1 protein 2 antibody; GATL2_HUMAN antibody; GATS-like protein 2 antibody; GATSL2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cytosolic arginine sensor for mTORC1 subunit 2 protein (82-329AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | A6NHX0 |
Uniprot Id
A6NHX0
Target Species
Human
Target Name
CASTOR2
Target Full Name
Cytosolic arginine sensor for mTORC1 subunit 2
Target Function
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
GATS family
Target Tissue Specificity
Widely expressed.
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