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The antibody against CCDC134 was raised in rabbit using the Recombinant Human Coiled-coil domain-containing protein 134 protein (23-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CCDC134 was raised in rabbit using the Recombinant Human Coiled-coil domain-containing protein 134 protein (23-229AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CCDC134 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using CCDC134 Antibody at dilution of 1:1002
| Cat.No | ADC-44071A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CCDC134 |
| Target Synonyms | CC134_HUMAN antibody; ccdc134 antibody; coiled-coil domain containing 134 antibody; Coiled-coil domain-containing protein 134 antibody; dJ821D11.3 antibody; FLJ22349 antibody; MGC21013 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Coiled-coil domain-containing protein 134 protein (23-229AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9H6E4 |
Uniprot Id
Q9H6E4
Target Species
Human
Target Name
CCDC134
Target Full Name
Coiled-coil domain-containing protein 134
Target Function
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling.; In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Target Subcellular Location
Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum.
Target Protein Families
CCDC134 family
Target Tissue Specificity
Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level). Also detected in placenta. Highest expression in
Target Synonyms
CC134_HUMAN; ccdc134; coiled-coil domain containing 134; Coiled-coil domain-containing protein 134; dJ821D11.3; FLJ22349; MGC21013
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