Rabbit anti-Human CDC45 Polyclonal Antibody

Uniprot Id

O75419

Target Species

Human

Target Name

CDC45

Target Full Name

Cell division control protein 45 homolog

Target Function

Required for initiation of chromosomal DNA replication.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

CDC45 family

Target Tissue Specificity

Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.

Target Synonyms

CDC 45; CDC 45L; CDC45 (cell division cycle 45; S.cerevisiae homolog) like; CDC45; CDC45 cell division cycle 45 like; CDC45 like; CDC45 related protein; CDC45_HUMAN; CDC45L2; Cell division control protein 45 homolog; Cell division cycle 45 like 2; Cell division cycle 45 like; PORC PI 1; PORC-PI-1

Target Background

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.