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The antibody against CERK was raised in rabbit using the Fusion protein of Human CERK as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against CERK was raised in rabbit using the Fusion protein of Human CERK as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-30604A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CERK |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Fusion protein of Human CERK | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8TCT0 |
Uniprot Id
Q8TCT0
Target Species
Human
Target Name
CERK
Target Full Name
Ceramide kinase
Target Function
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides. Binds phosphoinositides.
Target Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein.
Target Tissue Specificity
High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
Target Synonyms
Acylsphingosine kinase; Ceramide kinase; Cerk; CERK1_HUMAN; dA59H18.2; dA59H18.3; hCERK; KIAA1646; Lipid kinase 4; Lipid kinase LK4; LK4
Target Background
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).
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