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The antibody against CFHR1 was raised in rabbit using the Recombinant Human Complement factor H-related protein 1 protein (132-221AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CFHR1 was raised in rabbit using the Recombinant Human Complement factor H-related protein 1 protein (132-221AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-02791A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CFHR1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Complement factor H-related protein 1 protein (132-221AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q03591 |
Uniprot Id
Q03591
Target Species
Human
Target Name
CFHR1
Target Full Name
Complement factor H-related protein 1
Target Function
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
Target Subcellular Location
Secreted.
Target Tissue Specificity
Expressed by the liver and secreted in plasma.
Target Research Area
Cardiovascular
Target Synonyms
(FHR-1)(H factor-like protein 1)(H-factor-like 1)(H36)
Target Background
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
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