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The antibody against CINP was raised in rabbit using the Recombinant Human Cyclin-dependent kinase 2-interacting protein (1-212AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against CINP was raised in rabbit using the Recombinant Human Cyclin-dependent kinase 2-interacting protein (1-212AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-44500A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CINP |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cyclin-dependent kinase 2-interacting protein (1-212AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BW66 |
Uniprot Id
Q9BW66
Target Species
Human
Target Name
CINP
Target Full Name
Cyclin-dependent kinase 2-interacting protein
Target Function
Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.
Target Subcellular Location
Nucleus. Note=Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
Target Protein Families
CINP family
Target Research Area
Cell Biology
Target Synonyms
CDK2-interacting protein; CINP; CINP protein; CINP_HUMAN; Cyclin dependent kinase 2 interacting protein; Cyclin-dependent kinase 2-interacting protein; MGC849
Target Background
The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants.
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