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The antibody against CLN5 was raised in rabbit using the Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 protein (42-181AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against CLN5 was raised in rabbit using the Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 protein (42-181AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-06948A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CLN5 |
| Target Synonyms | Ceroid lipofuscinosis neuronal 5 antibody; Ceroid-lipofuscinosis neuronal protein 5 antibody; CLN5 antibody; CLN5_HUMAN antibody; NCL antibody; Protein CLN5 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 protein (42-181AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75503 |
Uniprot Id
O75503
Target Species
Human
Target Name
CLN5
Target Full Name
Bis(monoacylglycero)phosphate synthase CLN5
Target Function
Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
Target Involvement
Ceroid lipofuscinosis, neuronal, 5 (CLN5)
Target Subcellular Location
[Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5]: Membrane; Single-pass type II membrane protein.
Target Protein Families
CLN5 family
Target Tissue Specificity
Ubiquitous.
Target Research Area
Others
Target Synonyms
Ceroid lipofuscinosis neuronal 5; Ceroid-lipofuscinosis neuronal protein 5; CLN5; CLN5_HUMAN; NCL; Protein CLN5
Target Background
This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
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