Rabbit anti-Human COX11 Polyclonal Antibody

Uniprot Id

Q9Y6N1

Target Species

Human

Target Name

COX11

Target Full Name

Cytochrome c oxidase assembly protein COX11, mitochondrial

Target Function

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.

Target Protein Families

COX11/CtaG family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

COX11; COX11 homolog; COX11 homolog; cytochrome c oxidase assembly protein (yeast) ; COX11_HUMAN; COX11P; Cytochrome c oxidase assembly protein COX11; Cytochrome c oxidase assembly protein COX11; mitochondrial; Cytochrome c oxidase subunit 11; mitochondrial

Target Background

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.