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The antibody against CSNK1G2 was raised in rabbit using the Recombinant Human Casein kinase I isoform gamma-2 protein (316-415AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC, IP.
The antibody against CSNK1G2 was raised in rabbit using the Recombinant Human Casein kinase I isoform gamma-2 protein (316-415AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC, IP.
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Immunohistochemistry of paraffin-embedded human testis tissue using CSNK1G2 Antibody at dilution of 1:1002
| Cat.No | ADC-17041A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CSNK1G2 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB, IP | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Casein kinase I isoform gamma-2 protein (316-415AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P78368 |
Uniprot Id
P78368
Target Species
Human
Target Name
CSNK1G2
Target Full Name
Casein kinase I isoform gamma-2
Target Function
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Target Subcellular Location
Cytoplasm, cell cortex. Cytoplasm.
Target Protein Families
Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Target Tissue Specificity
Testis.
Target Synonyms
Casein kinase 1; gamma 2; Casein kinase I isoform gamma 2; Casein kinase I isoform gamma-2; CK1g2; CKI gamma 2; CKI-gamma 2; CSNK1G 2; Csnk1g2; KC1G2_HUMAN
Target Background
Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation. Located in membrane.
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