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The antibody against cTNT was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 1-288 of human cTNT (NP_001001430.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against cTNT was raised in Rabbit using the recombinant Protein corresponding to a sequence within amino acids 1-288 of human cTNT (NP_001001430.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of?paraffin-embedded Rat heart tissue using?cTNT Rabbit pAb at?a?dilution of?1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution.?Blue: DAPI for nuclear staining. Perform high pressure antigen retrieval with 0.01 M citrate buffer (pH 6.0) prior to IF staining.
| Cat.No | ADA-08466A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | cTNT |
| Target Synonyms | CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6; Cardiac troponin T (TNNT2) | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant Protein corresponding to a sequence within amino acids 1-288 of human cTNT (NP_001001430.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P45379-6 | Immunogen Sequence |
Uniprot Id
P45379
Target Species
Human
Target Name
TNNT2
Target Full Name
Troponin T, cardiac muscle
Target Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Target Involvement
Cardiomyopathy, familial hypertrophic 2 (CMH2); Cardiomyopathy, dilated 1D (CMD1D); Cardiomyopathy, familial restrictive 3 (RCM3)
Target Protein Families
Troponin T family
Target Tissue Specificity
Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in
Target Synonyms
CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6; Cardiac troponin T (TNNT2)
Target Background
This gene encodes the cardiac isoform of troponin T. The encoded protein is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy.
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