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The antibody against CXorf21 was raised in rabbit using the Recombinant Human Uncharacterized protein CXorf21 protein (1-301AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against CXorf21 was raised in rabbit using the Recombinant Human Uncharacterized protein CXorf21 protein (1-301AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human prostate cancer using CXorf21 Antibody at dilution of 1:100
| Cat.No | ADC-18302A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CXorf21 |
| Target Synonyms | CXorf21Protein CXorf21 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Uncharacterized protein CXorf21 protein (1-301AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HAI6 |
Uniprot Id
Q9HAI6
Target Species
Human
Target Name
CXORF21
Target Full Name
TLR adapter interacting with SLC15A4 on the lysosome
Target Function
Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.
Target Subcellular Location
Lysosome membrane. Endosome membrane. Nucleus. Cytoplasm.
Target Tissue Specificity
Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level). Expressed at low levels in T-cells and NK cells.
Target Synonyms
CXorf21Protein CXorf21
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