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The antibody against DDI2 was raised in rabbit using the Recombinant Human Protein DDI1 homolog 2 protein (1-211AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against DDI2 was raised in rabbit using the Recombinant Human Protein DDI1 homolog 2 protein (1-211AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-19845A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DDI2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein DDI1 homolog 2 protein (1-211AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q5TDH0 |
Uniprot Id
Q5TDH0
Target Species
Human
Target Name
DDI2
Target Full Name
Protein DDI1 homolog 2
Target Function
Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity.
Target Subcellular Location
Cytoplasm, cytosol. Chromosome.
Target Protein Families
DDI1 family
Target Synonyms
DDI1 DNA damage inducible 1 homolog 2; Ddi2; DDI2_HUMAN; DNA damage inducible 1 homolog 2 (S. cerevisiae); DNA damage inducible 1 homolog 2; DNA damage inducible protein 2; MGC14844; Protein DDI1 homolog 2; RP4-680D5.5
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