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The antibody against DET1 was raised in rabbit using the Recombinant Human DET1 homolog protein (15-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against DET1 was raised in rabbit using the Recombinant Human DET1 homolog protein (15-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human gastric cancer using DET1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using DET1 Antibody at dilution of 1:1002
| Cat.No | ADC-16557A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DET1 |
| Target Synonyms | DET1 antibody; DET1 homolog antibody; De-etiolated-1 homolog antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human DET1 homolog protein (15-240AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7L5Y6 |
Uniprot Id
Q7L5Y6
Target Species
Human
Target Name
DET1
Target Full Name
DET1 homolog
Target Function
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
Target Subcellular Location
Nucleus.
Target Protein Families
DET1 family
Target Tissue Specificity
Highly expressed in the ovary, some lymphoid organs and resting leukocytes.
Target Synonyms
DET1; DET1 homolog; De-etiolated-1 homolog
Target Background
Enables ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and protein-containing complex assembly. Part of Cul4A-RING E3 ubiquitin ligase complex.
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