Rabbit anti-Human DGKA Polyclonal Antibody

The antibody against DGKA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DGKA (NP_958852.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-02805A

Number

Cat.No	ADA-02805A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	DGKA
Target Synonyms	DAGK; DAGK1; DGK-alpha; DGKA	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Jurkat, Molt-4, SK-BR-3	Application	ELISA, WB

Cat.No

ADA-02805A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

DGKA

Target Synonyms

DAGK; DAGK1; DGK-alpha; DGKA

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Jurkat, Molt-4, SK-BR-3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DGKA (NP_958852.1).	Target Species	Human
Immunogen Sequence	MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTL	Uniprot ID	P23743

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human DGKA (NP_958852.1).

Target Species

Human

Immunogen Sequence

MAKERGLISPSDFAQLQKYMEYSTKKVSDVLKLFEDGEMAKYVQGDAIGYEGFQQFLKIYLEVDNVPRHLSLALFQSFETGHCLNETNVTKDVVCLNDVSCYFSLLEGGRPEDKLEFTFKLYDTDRNGILDSSEVDKIILQMMRVAEYLDWDVSELRPILQEMMKEIDYDGSGSVSQAEWVRAGATTVPLLVLLGLEMTL

Uniprot ID

P23743

Background Information

Uniprot Id

P23743
Target Species

Human
Target Name

DGKA
Target Full Name

Diacylglycerol kinase alpha
Target Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group. Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol.
Target Subcellular Location

Cytoplasm, cytosol.
Target Protein Families

Eukaryotic diacylglycerol kinase family
Target Tissue Specificity

Expressed in lymphocytes.
Target Research Area

Signal Transduction
Target Synonyms

80 kDa diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK alpha; DGK-alpha; dgkA; DGKA_HUMAN; Diacylglycerol kinase alpha; Diacylglycerol kinase; alpha 80kDa; Diglyceride kinase alpha; MGC12821; MGC42356; OTTHUMP00000242836; OTTHUMP00000242955; OTTHUMP00000244046
Target Background

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene.

Rabbit anti-Human DGKA Polyclonal Antibody

Specifications

Immunogen Information

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