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The antibody against DPPA4 was raised in rabbit using the Recombinant Human Developmental pluripotency-associated protein 4 protein (11-264AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against DPPA4 was raised in rabbit using the Recombinant Human Developmental pluripotency-associated protein 4 protein (11-264AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human testis tissue using DPPA4 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using DPPA4 Antibody at dilution of 1:1002
| Cat.No | ADC-22741A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DPPA4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Developmental pluripotency-associated protein 4 protein (11-264AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7L190 |
Uniprot Id
Q7L190
Target Species
Human
Target Name
DPPA4
Target Full Name
Developmental pluripotency-associated protein 4
Target Function
May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ectoderm lineage.
Target Subcellular Location
Nucleus.
Target Synonyms
2410091M23Rik; Developmental pluripotency associated 4; Developmental pluripotency associated protein 4; Developmental pluripotency-associated protein 4; Dppa 4; DPPA4; DPPA4_HUMAN; FLJ10713
Target Background
This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
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