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The antibody against DSC3 was raised in rabbit using the Recombinant Human Desmocollin-3 protein (712-896AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against DSC3 was raised in rabbit using the Recombinant Human Desmocollin-3 protein (712-896AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-05754A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DSC3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Desmocollin-3 protein (712-896AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14574 |
Uniprot Id
Q14574
Target Species
Human
Target Name
DSC3
Target Full Name
Desmocollin-3
Target Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Target Involvement
Hypotrichosis and recurrent skin vesicles (HRSV)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Target Tissue Specificity
Epidermis, buccal mucosa, esophagus and cervix.
Target Synonyms
Cadherin family member 3; CDHF3; desmocollin 3a/3b; Desmocollin 4; Desmocollin-3; Desmocollin-4; Desmocollin3; Desmocollin4; DSC; DSC1; DSC2; DSC3; DSC3_HUMAN; DSC4; HT CP; HT-CP; HTCP
Target Background
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.
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