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The antibody against ECE1 was raised in rabbit using the Recombinant Human Endothelin-converting enzyme 1 protein (471-770AA)) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against ECE1 was raised in rabbit using the Recombinant Human Endothelin-converting enzyme 1 protein (471-770AA)) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human skin tissue using ECE1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using ECE1 Antibody at dilution of 1:1002
| Cat.No | ADC-45032A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ECE1 |
| Target Synonyms | ECE1; Endothelin-converting enzyme 1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Endothelin-converting enzyme 1 protein (471-770AA)) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P42892 |
Uniprot Id
P42892
Target Species
Human
Target Name
ECE1
Target Full Name
Endothelin-converting enzyme 1
Target Function
Converts big endothelin-1 to endothelin-1.
Target Involvement
Hirschsprung disease, cardiac defects, and autonomic dysfunction (HCAD)
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Target Protein Families
Peptidase M13 family
Target Tissue Specificity
All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A an
Target Synonyms
ECE1; Endothelin-converting enzyme 1
Target Background
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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