Rabbit anti-Human EPO Polyclonal Antibody

Uniprot Id

P01588

Target Species

Human

Target Name

EPO

Target Full Name

Erythropoietin

Target Function

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.

Target Involvement

Microvascular complications of diabetes 2 (MVCD2)

Target Subcellular Location

Secreted.

Target Protein Families

EPO/TPO family

Target Tissue Specificity

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Target Research Area

Cancer

Target Synonyms

Epoetin

Target Background

This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies.