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The antibody against FLG was raised in rabbit using the Recombinant Human Filaggrin protein (3838-4061AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against FLG was raised in rabbit using the Recombinant Human Filaggrin protein (3838-4061AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human prostate tissue using FLG Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skin tissue using FLG Antibody at dilution of 1:1002
| Cat.No | ADC-49608A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FLG |
| Target Synonyms | ATOD2 antibody; Epidermal filaggrin antibody; FILA_HUMAN antibody; Filaggrin antibody; Filaggrin precursor antibody; Fillagrin antibody; FLG antibody; Profilaggrin antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Filaggrin protein (3838-4061AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P20930 |
Uniprot Id
P20930
Target Species
Human
Target Name
FLG
Target Full Name
Filaggrin
Target Function
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Target Involvement
Ichthyosis vulgaris (VI); Dermatitis atopic 2 (ATOD2)
Target Subcellular Location
Cytoplasmic granule.
Target Protein Families
S100-fused protein family
Target Tissue Specificity
Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal
Target Research Area
Signal Transduction, Cancer
Target Synonyms
ATOD2; Epidermal filaggrin; FILA_HUMAN; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin
Target Background
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
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