Rabbit anti-Human Folate Binding Protein(FBP) / FOLR1 Polyclonal Antibody

Uniprot Id

P15328

Target Species

Human

Target Name

FOLR1

Target Full Name

Folate receptor alpha

Target Function

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Target Involvement

Neurodegeneration due to cerebral folate transport deficiency (NCFTD)

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.

Target Protein Families

Folate receptor family

Target Tissue Specificity

Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.

Target Synonyms

adult; Adult folate binding protein; Adult folate-binding protein; FBP; Folate Binding Protein; Folate Receptor 1 Adult; Folate receptor 1; Folate Receptor 1 Precursor; Folate receptor adult; Folate receptor alpha; Folate receptor; FOLR; FOLR1; FOLR1_HUMAN; FR alpha; FR-alpha; FRalpha ; KB cells FBP; MOV18; Ovarian cancer associated antigen ; Ovarian tumor associated antigen ; Ovarian tumor associated antigen MOv18; Ovarian tumor-associated antigen MOv18

Target Background

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.