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The antibody against GLRX2 was raised in rabbit using the Recombinant Human Glutaredoxin-2, mitochondrial protein (1-124AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against GLRX2 was raised in rabbit using the Recombinant Human Glutaredoxin-2, mitochondrial protein (1-124AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human colon cancer using GLRX2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using GLRX2 Antibody at dilution of 1:1002
| Cat.No | ADC-44759A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GLRX2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Glutaredoxin-2, mitochondrial protein (1-124AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NS18 |
Uniprot Id
Q9NS18
Target Species
Human
Target Name
GLRX2
Target Full Name
Glutaredoxin-2, mitochondrial
Target Function
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Target Subcellular Location
[Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
Target Protein Families
Glutaredoxin family
Target Tissue Specificity
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
Target Research Area
Signal Transduction
Target Synonyms
bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); bA101E13.1; CGI133; Glrx2; GLRX2_HUMAN; Glutaredoxin-2; Glutaredoxin-2; mitochondrial; GRX2; mitochondrial
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