Rabbit anti-Human GNB4 Polyclonal Antibody

Uniprot Id

Q9HAV0

Target Species

Human

Target Name

GNB4

Target Full Name

Guanine nucleotide-binding protein subunit beta-4

Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Target Involvement

Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)

Target Protein Families

WD repeat G protein beta family

Target Tissue Specificity

Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.

Target Synonyms

G protein beta 4 subunit; GBB4_HUMAN; GNB 4; Gnb4; Guanine nucleotide binding protein (G protein) beta polypeptide 4; Guanine nucleotide binding protein beta 4 subunit; Guanine nucleotide binding protein beta polypeptide 4; Guanine nucleotide binding protein beta subunit 4; Guanine nucleotide binding protein subunit beta 4; Guanine nucleotide-binding protein subunit beta-4; Transducin beta chain 4

Target Background

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.