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The antibody against HEXB was raised in rabbit using the Synthesized peptide derived from C-terminal of Human HEXB. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against HEXB was raised in rabbit using the Synthesized peptide derived from C-terminal of Human HEXB. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Western blot analysis of extracts from Jurkat cells, using HEXB antibody.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using HEXB antibody.2
| Cat.No | ADC-42167A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HEXB |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from C-terminal of Human HEXB. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P07686 |
Uniprot Id
P07686
Target Species
Human
Target Name
HEXB
Target Full Name
Beta-hexosaminidase subunit beta
Target Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.
Target Involvement
GM2-gangliosidosis 2 (GM2G2)
Target Subcellular Location
Lysosome. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
Target Protein Families
Glycosyl hydrolase 20 family
Target Research Area
Metabolism
Target Synonyms
Beta hexosaminidase beta chain; Beta hexosaminidase subunit beta; Beta N acetylhexosaminidase; Beta-hexosaminidase subunit beta chain A; Beta-N-acetylhexosaminidase subunit beta; Cervical cancer proto oncogene 7 protein; Cervical cancer proto-oncogene 7 protein; ENC 1AS; Epididymis luminal protein 248; HCC 7; HCC-7; HCC7; HEL 248; HEX B; Hexb; HEXB_HUMAN; Hexosaminidase B (beta polypeptide); Hexosaminidase B; Hexosaminidase subunit B; HexosaminidaseB; N acetyl beta glucosaminidase; N-acetyl-beta-glucosaminidase subunit beta
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