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The antibody against HFE was raised in rabbit using the Recombinant Human Hereditary hemochromatosis protein (23-306AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against HFE was raised in rabbit using the Recombinant Human Hereditary hemochromatosis protein (23-306AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-20154A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HFE |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Hereditary hemochromatosis protein (23-306AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q30201 |
Uniprot Id
Q30201
Target Species
Human
Target Name
HFE
Target Full Name
Hereditary hemochromatosis protein
Target Function
Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Target Involvement
Hemochromatosis 1 (HFE1); Variegate porphyria (VP); Microvascular complications of diabetes 7 (MVCD7)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
MHC class I family
Target Tissue Specificity
Expressed in all tissues tested except brain.
Target Research Area
Metabolism
Target Synonyms
dJ221C16.10.1; Hemochromatosis; Hemochromatosis protein; Hereditary hemochromatosis protein; Hereditary hemochromatosis protein HLA H; HFE 1; HFE; HFE_HUMAN; HFE1; HH; High Fe; HLA H; HLA-H; HLAH; MGC:150812; MGC10379; MGC103790; MHC class I like protein HFE; MVCD7; TFQTL2
Target Background
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene.
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