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The antibody against HTR4 was raised in rabbit using the Recombinant Human 5-hydroxytryptamine receptor 4 protein (316-388AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against HTR4 was raised in rabbit using the Recombinant Human 5-hydroxytryptamine receptor 4 protein (316-388AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human small intestine tissue using HTR4 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using HTR4 Antibody at dilution of 1:1002
| Cat.No | ADC-08924A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HTR4 |
| Target Synonyms | HTR4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human 5-hydroxytryptamine receptor 4 protein (316-388AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13639 |
Uniprot Id
Q13639
Target Species
Human
Target Name
HTR4
Target Full Name
5-hydroxytryptamine receptor 4
Target Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endosome.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.
Target Synonyms
HTR4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4
Target Background
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
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